2 failed IVF & + ANA

heb331

0 Posts
Reply 2 failed IVF & + ANA Posted on: Mar 7, 2011 at 11:58pm
hello,

i live in south carolina and have been undergoing fertility treatments for 2.5 yrs. i will make a long story as short as i can. i have a 4 yo daughter who we conceived naturally, but during delivery placental parts were left in me which lead to a d & c 4 wks later. the d & c caused ashermann's syndrome which caused me to have 2 laprosocopy with hysteroscopy (sorry if i am spelling these all wrong!). i have had 2 hsgs, been on clomid, and done several iuis. my uterine lining never got super thick, but did have triple layer. i switched drs and she didn't recommend clomid due to it stripping lining, so she had me try a number of other drugs with more iuis. nothing happened. so i did ivfs. i responded well, but she said apparently i have "implantation failure". she did a blood panel on me which revealed i have double MTHFR & +ANA. after 2 yrs she referred me to another dr who specializes in endometriosis. he did another lap & found a bit of endo (stage 1). he also punctured my uterine wall during surgery. this month i did femara, lovenox, and progesterone. i feel like i am abt to get my period due to terrible back pain. that's the other part to the story i have been to neurologist, rheumotologists, and hematologist and had lp, mris and xrays..the whole 9 yards! i have no other signs of lupus or any other autoimmune disorder. they labled it undifferentiated connective tissure disorder or fibromyalgia. my back hurst so terribly bad 2 wks before my period. my legs tingle and hurt. i about at the end of my rope with doctors, procedure, no diagnosis and NO PREGNANCY! boo! could the infertility and ANA/pain be related to 1 disorder? is there any help for me to get pregs? i am otherwise a healthy 33 yo. thank you for any help you can provide!!!!! betsy

Dr. Braverman

2024 Posts
Re: 2 failed IVF & + ANA Posted on: Mar 8, 2011 at 6:04am
There are 2 issues that come into play here. First, what was the "thickest" you were able to get your endometrium after your D and Cs? how was the ashermans treated, this alone could be your problem. Second the ANA by itself with or without the diagnosis of an underlying collagen vascular disease could be playing a role as well. As we have stated on this website the ANA's may be attaching directly to the trophoblastic tissue and leading to your losses.
The ANA is very treatable and there are experimental protocols we are working on for thin uterine lining. I would be happy to help you with your case. If you want to set up a consult, please call my office and ask for Kim . I hope I can be of service to you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

heb331

0 Posts
Reply Re: 2 failed IVF & + ANA Posted on: Mar 8, 2011 at 5:16pm
thank you for your reply. i have tried vivelle path therapy (up to 4 patches), accupuncture, baby asprin, estrace to thicken lining. it is usually about 7mm to 9mm. i have been tested & biopsied & no one knows what to do with me literally..they tell me this. the ashermans was treated by the 2 laproscopy with lysis of adhesions and hysteroscopys (diagnosed asherman's syndrome with uterine synechiae).

fertiltiy drugs i have been on: (some of these may be the same thing & i can't recall them all)
clomid
letrozole
follistim
femara
provera
prometrium
bravelle
ovidrell
lupron
hcg
endometrin
preseed
crinone
if you think you can help me that would be wonderful. my faith in doctors in waning.

Dr. Braverman

2024 Posts
Re: 2 failed IVF & + ANA Posted on: Mar 13, 2011 at 2:08am
lining of 7 to 9mm is really not bad, not c/w a diagnosis of ashermans, there must be something esle here and again I suspect the pos ANA. I think there is still much you can do , I would be happy to help guide you. Feel free to call my office and set up a consultation , ask for Kim. I hope I can be of service to you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.