2nd donor egg cycle just failed 10 years trying 5 losses

DSPS

1 Posts
Reply Posted on: Sep 10, 2015 at 7:27am
Dr. Braverman,


I am at a complete loss. We just found out our 2nd IVF donor egg cycle failed. I am 46 years old. I have had 3 miscarriages prior to any treatment. First blighted ovum at 12 weeks, 2nd and third were 5 week and 7/8 weeks. We sought out first RE. I was age 40. He immediately recommended IVF with donor eggs. We wound up doing an iui for financal reasons. I became pregnant the first try. Betas were low and I miscarried. We then went on to 4 more iui's all negative. After a year we moved towards IVF donor egg with a shared cycle. I only had 1 embryo from that and they did a 3 day transfer. I became pregnant. Betas were good and when we went in for the heartbeat ultrasound there was nothing there. I wound up consulting with another doctor from a friends recommendation because everything I read I thought I had elevated natural killer cells although first doctor said it was my age and eggs. The 2nd doctor did the immune testing and it turns out that we have a partial dq alpha and I have elevated natural killer cells. We were told our chances were about 30 percent. We just fininished a fresh ivf donor egg cycle and it failed. The donor was 26 and we transferred a "perfect" blast. I have 6 embryos frozen from this cycle. The protocol was prednisone (10 mg) and Intralipid, folic acid. Needless to say we are devestated. We just spent a small fortune and now we don't know what to do. Emotionally and financially we can't keep setting ourselves up for failure. I am hoping you can give me some insight.

Our immune results are as follows

Me:

HLA Genotype

DQ Beta 03,03

HLA A 26,32

HLA B 35,51

HLA C 04,15

HLA DRB1 08,11,DRB3 Present

DQ Alpha 4.1 4.1

NK Cell assay with 1vlg

te 1.50 native 9.7

TR 1.25 native 7.0

te 1.12.5 native 4.4

1.50 with IL-2 stim 10.4

1.25 6.2

1.12.5 5.1

1.50 ivlg 12.5 7.5

1.25 7.3

1.12.5 5.1

1.150 ivlg6.5 8.1

1.25 6.2

1.12.5 2.5

NK cell acitvation with inralipid

te 1.50 native 10.5

1.25 7.4

1.5 with il-2 stim 9.6

1.25 9.7

1.12.5 6.1

1.50 1:2000 13.5

1.25 8.2

1.125 6.2


WHO 6.7

Thab .01

antiphospolid antibody report all in normal range


husband:

Dq beta 03,06

HLA a 01,03

b 51,52

c 01,12/03

HLA PRB1 11,15,FRB3, DRB5 present

DQ alpha 1.3, 4.1


Sorry for the long post but I don't know what else to do. I am now 46 and feel like my time is running out. I don't want to keep failing. I don't want to use those frozen embryos if I am going to keep rejecting them. Thank you for your time
Dina

Dr. Braverman

2017 Posts
RE: 2nd donor egg cycle just failed 10 years trying 5 losses Posted on: Sep 10, 2015 at 7:37am
You clearly have an autoimmune Haplotype and most likely therfore have an underlying autoimmune issue as the root cause of these failures. I suggest you set up a free consult with me so we can reveiw your history in detail. Fill out a consult request from the website.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.