43 yrs old and 11 miscarriages with immune issues

horserider

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Reply 43 yrs old and 11 miscarriages with immune issues Posted on: Oct 10, 2011 at 2:38am
Dear Dr. Braverman,

I learned about you on an immunology board. Let me say how impressed I am that you take this time to help others. This is very unusual for a doctor. I'll be in NYC for a check up with my RE, and I am hoping to get a consult with you while there from out of state. Thank you in advance for assisting me.

I am a patient at AEB since March, 2011. I've had every doctor tell me to use donor egg and that I'd never conceive, but I have 11 times. All naturally, and 5 with IUI from age 39-42. My last natural pregnancy was a year ago. Each ended between 5-10 weeks. Inconclusive chromosome testing. AEB results: Borderline crossmatch at 33.8 (LAD); antiphospholipid antibody was positive; ANA was negative; Anti-ovarian was negative; Hashimoto's Disease; TSH=0.344; 50:1=20; 25:1=8.5, Cytokines 42.2; CD56=21.8; T-Reg=0.4; MTHFR A Homozygous, and AMH=.046.

I take Synthroid 75mcg, Baby Aspirin, Acyclovir 800 mg daily (the first cold sore break out ever was on my cheek after EACH IVIG treatment), two IVIG treatments in one month which followed with severe chest congestion and persistent coughing that lasted over 6 weeks; Humira; LIT, Folgard, Lovenox 30mg, Magnesium, Fish Oil, Prenatal Vitamin.

To make a long story short, after one LIT treatment in Nogales, my LAD went to 77.8 in May. After 2 Humira shots, my T Reg went to 1.2 in June; BUT AFTER 2 IVIG TREATMENTS, my 50:1=22.1, 25:1=17.2; CD56=11; Cytokines=43.8. I became very ill after IVIG with chronic cough and fatigue, and cold sores on my face (which, as mentioned, I've never had; hence, the daily meds to keep this at bay.) AEB thought maybe the cold sores were the cause of my elevated levels and the cause of no response to IVIG, but after 5 weeks of taking acyclovir, my levels have not improved.

SHOULD I USE DONOR EGG at 43 with an AMH of .046? If you say yes, I will do this and move past one obstacle. Secondly, CAN YOU HELP ME TO LOWER THESE LEVELS if I consult with you? Can INTRALIPIDS help me instead of IVIG? Not sure where to go. I'd like to do my first IVF cycle, but need to get all levels in order, AND I CANNOT TRAVEL BACK TO MEXICO FOR LIT. I'm past the end of my rope.

Dr. Braverman

1998 Posts
Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Oct 10, 2011 at 6:19pm
ok I can see you've been through quite a bit. Firslty donor egg always makes it easier at you dont have to worry about chromosomal abnormalities as the cause of your losses. It is certainly still possible to concieve with your own eggs just very low chance at age 43. If you look on my boards you can see I have several of these patients.

I do feel that all your losses are immune related if not genetic and there are things that we can do to help the cytokine levels and treat this even if you perform donor egg. Not sure for the reason for the cold sores but immunosuppression is the main reason for reactivation.

Please schedule a consultation for when you are in NY and bring all your records and we can go over all.
Speak to you soon , do not despair.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

horserider

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Reply Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Oct 10, 2011 at 7:59pm
God Bless, and thanks. Look forward to meeting you.

carrie50

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Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Oct 10, 2011 at 9:38pm
So would it be a safe bet that if you already prone to cold sores and are embarking on immune treatments you should be prepared for outbreaks?

I have also used L Lysine as a preventive and treatment in the past with some success, would this be alright to add as a supplement to daily vitamins and supplements?

Dr. Braverman

1998 Posts
Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Oct 13, 2011 at 12:39am
yes outbreaks are not unusual.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

horserider

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Reply Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Nov 17, 2011 at 12:26am
Dr. Braverman,

I can't get to you soon enough. I was cleared by AEB to start my IVF cycle, but I'm feeling uneasy about things. I am on day 1 of Follistim, and I wish that I could Skype with you to review my results. You are a very busy man, rightfully so. I've found some success with ILs SLOWLY lowering my TNF and NKs that are now 35 and 20. I'm thinking I need your advise on Neupogen. I'm so overwhelmed and confused... maybe it's time to give up after 11 miscarriages. My MFM doctor changed my Lupron to Heparin, and I'm already taking Dex. I need help lowering my NKs and TNF and T-Reg. Can you PLEASSSSSSEEEEEEE help me. I'm frightened now.

Dr. Braverman

1998 Posts
Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Nov 17, 2011 at 5:32am
where do you live? trying to get an idea on time zone and when we could have a consultation after hours.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

horserider

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Reply Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Nov 17, 2011 at 5:35am
Orlando... same time zone as you.

Dr. Braverman

1998 Posts
Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Nov 17, 2011 at 9:23pm
call my office now as I can speak with you over the next couple of hours.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

horserider

0 Posts
Reply Re: 43 yrs old and 11 miscarriages with immune issues Posted on: Nov 17, 2011 at 9:33pm
Just did... spoke with Kim; she said she'd email you letting you know that I called. Thanks, Robin