APS and other clotting disorders


1 Posts
Reply Posted on: Jul 10, 2012 at 9:53pm
Hi Dr Braverman,

I was wondering if you could please explain a few things for me.
I have included a little history:

  • I am 33 years old and had Thrombocytopenia my whole live.
  • I had a Pulmonary Embolism at 22, and was positive for smooth muscle antibodies, negative for Lupus.
  • I had two miscarriages in the last 2 years.
  • Test Results for the last 8 months indicated Anti-beta2Glycoprotein repeatedly elevated at around 24-30 .
  • IgG and IgM were normal (upper) limit.
  • Therefore I was diagnosed with Antiphospholipid Syndrome by my doctor.
  • Recently another doctor tested me for various issues and said that I had the Pro-Thrombin Gene Mutation.

I am just trying to get my head around these issues and would like to know:

  • Antiphospholipid Syndrome is associated with Thrombocytopenia - how is that?
  • Is there a correlation between the Pro-thrombin gene mutation and thrombocytopenia and elevated Autoimmune Antibodies?
  • Does the Pro-thrombin Gene Mutation cause Thrombocytopenia, or does the body try to compensate with lower platelets to counteract the hypercoagulability?
  • I heard about IgG food sensitivity testing and was wondering if that would be useful in determining if food allergens could possibly be the culprits in causing the auto-immune antibodies in the case of Anti-beta2 Glycoprotein antibodies.

Thank you very much for your time.

Kind regards,

Dr. Braverman

2024 Posts
RE: APS and other clotting disorders Posted on: Jul 11, 2012 at 6:29am
It sounds like your all over the place here. Yes you can have thrombocytopenia with APS, cause is not clear, but I would suspect from agglutination of platelets "sticking" togehter eventually lowers their counts. Here is a reference for you.


If you are having any issues with this as it relates to pregnancy loss I suggest you call me as there are many issues that need to be studied and resolved in a clear fashion. Its all very treatable.

Good Luck , I hope this helps.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.