Elvated TNF-a / IFN-g

Hadleigh

35 Posts
Reply Elvated TNF-a / IFN-g Posted on: Sep 23, 2011 at 8:07am
Dr. Braverman,
My TNF-a (38.2) and IFN-g levels (21.0) are elevated...is it be best to lower these levels prior to a FET if all other immune tests are within normal ranges? Also, how would you go about treating when all other testing is normal? Thanks.

Dr. Braverman

2004 Posts
Re: Elvated TNF-a / IFN-g Posted on: Sep 23, 2011 at 11:55pm
The problem with the elevated cytokines that you listed is that they make it harder for the embryo to develop immune tolerance in the mother and lowers the success rates. Eventually elevated levels will activate the other immune cells. In this situation I prefer to use prednisone as a treatment during the FET cycle.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Hadleigh

35 Posts
Reply Re: Elvated TNF-a / IFN-g Posted on: Sep 28, 2011 at 2:35am
How much Pred would you use in a case like this and for how long? Thanks you.

Dr. Braverman

2004 Posts
Re: Elvated TNF-a / IFN-g Posted on: Sep 28, 2011 at 4:29pm
at least 20mg but I would need to see the remainder of my immune profile to give you definitive recommendations as this could change my thoughts.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Hadleigh

35 Posts
Reply Re: Elvated TNF-a / IFN-g Posted on: Sep 28, 2011 at 10:41pm
How much Dex equals 20 mg of Pred? Also, does Dex and Pred work the same way and are both equally effective? I have heard that Dex crosses over the placenta, but Pred does not. Thank you for you time in answering our questions. You are appreciated.

Hadleigh

35 Posts
Reply Re: Elvated TNF-a / IFN-g Posted on: Sep 29, 2011 at 10:52pm
How much Dex would work the same as 20mg of Pred? Also, are both steriods as effective as the other? I do understand that Dex crosses over the placenta, but Pred does not. Thank you for you commitment in answering our questions. Have a great day.

LuAnne

0 Posts
Re: Elvated TNF-a / IFN-g Posted on: Oct 1, 2011 at 11:03pm
In your reply to Lizib, you said that you would probably use 20mg Prednisone. How many mg of Dexamethasone would be equal to that? My doctor uses Desamethasone.

Dr. Braverman

2004 Posts
Re: Elvated TNF-a / IFN-g Posted on: Oct 3, 2011 at 6:21pm
I dont like dex for this as it crosses the placenta but 90-95% of prednisone gets broken down by the placenta and does not get the baby. Most use dex for routine IVF as it is stopped will prior to fetal circulation.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.