G-CSF and GM-CSF

Sandra

1 Posts
Reply Posted on: Dec 4, 2013 at 10:06am
Dear Dr. Braverman,

I understand that G-CSF appears promising in patients that 1) have a thin uterine lining or 2) are missing the 2 DS 1, 2 DS 3 and 3 DS 6 activating receptors (KIR or killer-cell immunglobin-like receptors). If a patient does not have either of the above issues, but has experienced implanation issues (including moderate to extremely strong uterine contractions 4-8 days after transfer), would using G-CSF be harmful? Or would it just not have any impact? Also, how does the G-CSF differ from the GM-CSF? Do you use GM-CSF in your practice?
Sandra Sobotka

Dr. Braverman

1998 Posts
RE: G-CSF and GM-CSF Posted on: Dec 4, 2013 at 10:27am
G-CSF and GM CSF are different cytokines that have ovarlapping qualities but also many different. We only have used G-CSF. Therre are many indicaitons for the use of G-CSF and KIR receptors are only one of many. For me to address if these are helpful for you I would need to know your complete history as well as a COIMPLETE immunology profile.
If you would like me to assist you please fil out a consult request on our website and we will be in touch with you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.