Insulin Resistance?

sunshineplease

2 Posts
Reply Posted on: May 3, 2012 at 10:48am
Dr Braverman,

I was recently tested for Insulin Resistance. This was based on my FSH (10.1) and LH (15). My results for the IR were as follows:

Glucose Tolerance Test
Fasting: 84 mg/dL
1 hour: 97 mg/dL
2 hour: 75 mg/dL

Insulin Response to Glucose
Fasting: 5 uIU/mL
1 hour: 27 uIU/mL
2 hour: 23 uIU/mL

Based on these results, my RE said I need to start Metformin before IVF in June. I am unsure how to interpret this--are these results abnormal? Please assist and let me know what you think.

Thanks.

Dr. Braverman

2027 Posts
RE: Insulin Resistance? Posted on: May 3, 2012 at 11:08am
there is no perfect way to screen for insulin resistance, they did the appropriate tess and they are borderline at best. I base the need for metformin on many issues including previous response to IVF , clinical symptoms, and of course your LH/FSH ratio. In general I have found the time to start metformin is when you are "thinking" about starting metformin. Remmber I always also look at your previous IVF or pregnancy loss history to help in this determination.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

sunshineplease

2 Posts
Reply RE: Insulin Resistance? Posted on: May 3, 2012 at 4:17pm
I have never done IVF. I am considering it for family balancing purposes and fertility preservation.

I have no clinical symptoms consistent with PCOS, no miscarriage history.
My RE (different state) was basing the recommendation for Metformin based on the aformentioned IR results and my day 3 FSH (10.1) and LH (15).

I am just confused because my local RE said I am NOT IR/PCOS and I don't know what is accurate?

Dr. Braverman

2027 Posts
RE: Insulin Resistance? Posted on: May 4, 2012 at 8:05am
Its becasue your levels are borderline that you are getting different opinions. In this case because there are no clinical findings or history , I might agree to hold off on the metformin and only start it should the outcome of an IVF cycle not be optimal.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.