Is it dangerous to use lovenox with low normal platelets?

lili

5 Posts
Reply Posted on: Aug 21, 2014 at 11:50am
Hi, Dr. Braverman:

Genetically, I have greater chance of clotting (PAI-1 Gene 4G/5G heterogeneous mutation, and MTHFR A1298C homozygous mutation).

But I am not sure if I have blood coagulation disorder assuming it is different from having higher risk of getting the disorder due to genes.

My antiphospholipid Ab tests fluctuate between positive to borderline.My aptt (activated partial prothrombin time) is 25 seconds where normal range is 25 to 30 seconds.My beta fibrinogen 455G/a gene polymorphism test is normal.

I have high positive SSA, ANA tier 160. But negative on other antibodies (lupus anticoagulant, anticardiolipin, etc).

The problem is my platelet is always low normal (
lili

Dr. Braverman

2027 Posts
RE: Is it dangerous to use lovenox with low normal platelets? Posted on: Aug 23, 2014 at 10:36am
You can use lovenox in most of these cases , depends on how low they are. With the history you are giving me it would be worthwhile for you to call me and discuss this case before you proceed with any management decisions. YOu can fill out a consult form on our website and we will schedule a free 10 minute discussion .
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

lili

5 Posts
Reply RE: Is it dangerous to use lovenox with low normal platelets? Posted on: Aug 24, 2014 at 4:35pm
Hi, Dr. Braverman:

Thanks so much for the reply!

My platelets was usually around 160 where the normal range is 140 to 415.
My most recent result was 200 (pregnant 5 wks).

Do you have a platelets threshold when you will suggest to stop lovenox?

Thanks.
lili
lili

Dr. Braverman

2027 Posts
RE: Is it dangerous to use lovenox with low normal platelets? Posted on: Aug 25, 2014 at 11:06am
it depends more on the reason for low platelets not just the number, if we do not suspect anti heparin antibodies and the platelets do not fall with the lovenox dose then even at 60K we have used the lovenox. Please be sure to always check with your doctor before starting any medicaitons as I do not know your complete history.
it depends more on the reason for low platelets not just the number, if we do not suspect anti heparin antibodies and the platelets do not fall with the lovenox dose then even at 60K we have used the lovenox. Please be sure to always check with your doctor before starting any medicaitons as I do not know your complete history.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.