Is it possible that I have been over suppressed with steroids

Fiona in Welwyn GC

3 Posts
Reply Posted on: Sep 26, 2012 at 12:40am
I am writing to you in my last ditch attempts of donor egg ivf before moving on to surrogacy. We have spent £100,000 trying to have a baby. As you can see from my profile at the bottom, I have had 6 chemical/early miscarriages (2 from own egg at 41/42 and 4 from donor).My miscarriage consultant in the UK diagnosed me with Very High Natural Killer cells (also th1/th2 ratio is very high) and put me on a treatment programme of 40mg of prednisolone and intrallipids. Prior to this I had four consecutive pregnancies. Since this treatment I have had four negative cycles despite good embryos (13 in total).I am totally baffled by what has happened. How could I possibly get pregnant twice with my 'old embryos' (very few to choose from) and now not able to get pregnant with young donor eggs with good blastocysts.Here are my questionsIs it possible that the steriods are over-supressing me and preventing implantation?Do you think Neupogen might help me?I don't really want to do surrogacy because I have already had to give up my genes, but I really am emotionally exhausted and I just can't take many more negative outcomes.We have the following frozen on day 52 x hatching blasts3 x expanded blasts1 x non expanded blastAny help whatsoever would be really appreciated.Kind regardsFiona--------------------Here's my brief details so far ..Me Age 45 DH 44 - MF and LORICSI#1 ARGC Nov08, 7 eggs, 6 emb, 3 blasts - BFP! Chem PregICSI#2 ARGC May09 2 emb BFNICSI#3,4,5 Lister - I missed miscarriage from 3 cyclesDEIVF#1 Jul- 15 egg 2xB blasts, chemDEIVF#2 Sep- 17 egg, 2 B Blast, m/cDEICSI#3 Mar- 16Emb D4- 3xgrade A BFP hcg 1240(15dpo) m/cDDIVF#4Jun 2xAblasts.HCG 78 14 dpo.m/cAug 2011 - High NKCFET#1 Sept BFNAll cycles from here on had 40 mg Prednisolone and intrallipids 7 days before transferDICSI#5 jan 2012 +imms 3 blasts. BFNDEIVF#6, April 2012 4 x 8 cell good embies BFNDEIVF#7 May 2012 4 x good blastocysts BFNMoved to Reprogenesis, CzechDEIVF#8 PICSI & embryoscopeET. 1st Sep 2012 2 x hatching blastocyst on day 5. BFN!!!!!(out of 9 fertilised eggs, we had four hatching blasts, 2expanded blasts and one none expanded blastocyst. All good enough to freeze
Me Age 45 DH 44 - MF and LOR
ICSI#1 ARGC Nov08
7 eggs
6 emb
3 blasts - BFP! Chem Preg
ICSI#2 ARGC May09  2 emb BFN
ICSI#3
4
5 Lister -  I missed miscarriage from 3 cycles
DEIVF#1  Jul- 15 egg  2xB blasts
chem
DEIVF#2 Sep- 17 egg
2 B Blast
m/c
DEICSI#3 Mar- 16 Emb D4- 3xgrade A BFP hcg 1240(15dpo) m/c
DDIVF#4Jun 2xAblasts.HCG 78 14 dpo.m/c
Aug 2011 - High NKC
FET#1 Sept BFN
DICSI#5 jan 2012 +imms 3 blasts.  BFN
Serum
Feb 2012 + hidden C and hysto
DEIVF#6
7 BFN
Reprogenesis
DEIVF#8 PICSI & embryoscope
ET. 1st Sep 2012
4XHB
2xEB
1Xblast
PUPO 2xHB
BFN  ... Why oh why oh why???

Dr. Braverman

2016 Posts
RE: Is it possible that I have been over suppressed with steroids Posted on: Sep 26, 2012 at 7:33am
I am sure I can help you make this decision regarding a surrogae , but you will need to call me and we can do a SKYPE consultation so I can carefully go over your records and your history. You can call our office to scehdule and we will arrange this for you. There still may be other therapies or as you suggested removal of therapies that may allow you to proceed on your own.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Fiona in Welwyn GC

3 Posts
Reply RE: Is it possible that I have been over suppressed with steroids Posted on: Sep 27, 2012 at 3:02am
Thank you. That is very kind of you

I will contact the office
Me Age 45 DH 44 - MF and LOR
ICSI#1 ARGC Nov08
7 eggs
6 emb
3 blasts - BFP! Chem Preg
ICSI#2 ARGC May09  2 emb BFN
ICSI#3
4
5 Lister -  I missed miscarriage from 3 cycles
DEIVF#1  Jul- 15 egg  2xB blasts
chem
DEIVF#2 Sep- 17 egg
2 B Blast
m/c
DEICSI#3 Mar- 16 Emb D4- 3xgrade A BFP hcg 1240(15dpo) m/c
DDIVF#4Jun 2xAblasts.HCG 78 14 dpo.m/c
Aug 2011 - High NKC
FET#1 Sept BFN
DICSI#5 jan 2012 +imms 3 blasts.  BFN
Serum
Feb 2012 + hidden C and hysto
DEIVF#6
7 BFN
Reprogenesis
DEIVF#8 PICSI & embryoscope
ET. 1st Sep 2012
4XHB
2xEB
1Xblast
PUPO 2xHB
BFN  ... Why oh why oh why???

Dr. Braverman

2016 Posts
RE: Is it possible that I have been over suppressed with steroids Posted on: Sep 27, 2012 at 6:00am
You quite welcome , I look forward to speaking with you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.