KIR test necessary before treating with neupogen?

kdb

4 Posts
Reply Posted on: Nov 1, 2012 at 3:38pm
Hi Dr Braverman

Do you recommend the KIR test before treating with neupogen?

I have a son from my first IVF however our next cycle (FET) was negative, despite all going well and two very good quality blastocysts. We used exactly the same protocol (Prednisolone, Clexane, Intralipids, Progesterone in Oil).

I would like to use neupogen with our next FET and understand from one of the studies that pregnancy rates for women who have the KIR receptors were adversely affected; the opposite being true for women missing the receptors.

I feel like I should have the test just to be sure neupogen would be a good alternative to steroids in my case.

[PCOS, Hashimoto's, elevated NK, borderline TNFa, MTHFR hetero]

Many thanks

Dr. Braverman

1999 Posts
RE: KIR test necessary before treating with neupogen? Posted on: Nov 2, 2012 at 8:34am
There should be a complete immune profile performed and a carefull assesment of your clinical history prior to the decision for neupogen. There is no data on the need for a KIR test , it was used as a "immune" basis to add patients to a protocol for neupogen in Germany, but it was never determined to be a test that was necessary.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.