Letrozole despite previous successful pregnancy.


1 Posts
Reply Posted on: Mar 8, 2012 at 8:56am
To give you a bit of history I am 32 and have endometriosis. My partner has oligozoospermia.

We have undergone several ICSI treatments over the last 6 years.

The first resulted in a chemical pregnancy
The second was a miscarriage at 8.5 weeks
The third resulted in our daughter
The forth there was no implantation
The fifth there was no implantation.

As I have endometriosis (although I am unsure of the grade) it has been suggested to me that I take Letrozole with our next cycle, based on the findings of your work showing increased implantation rate in women with endometriosis who take 5 days of letrozole due to the absence of an integrin in the endometrial lining.

I just wondered whether you thought that seeing as prior to my daughter we had no problems with implantation (as such) this would be something that might be beneficial, or whether I am unlikely to lack this integrin based on my history.


Dr. Braverman

2016 Posts
RE: Letrozole despite previous successful pregnancy. Posted on: Mar 10, 2012 at 8:13am
its not just the beta integrin but the deactivation of the aromatase enzyme that assists in implantation and this could have changed since your last child. I see no harm and only benefit. Good Luck.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.