Low oestradiol during pregnancy

Mayaus

10 Posts
Reply Posted on: Jun 30, 2014 at 8:01pm
Hello Dr Braverman,

I am 14 weeks pregnant after an egg donation cycle and have been on progynova (oestradiol) and progesterone support. I was told to wean off progynova from week 12 and test while I was weaning off. Last week I got back results from my oestradiol and I am muuuuuch below the range (1967 pmol/l and the range is 14000 to 24000 ). The clinic believes I am fine and ok to stop progynova (now I am only on a minimum dose of 2mg per day) but I am so scared to see these low levels of E2 and not sure if I should stop the progynova or increase it (I was on 4 tablets daily and reduced gradually to one only from week 12). I also wonder why are my levels so low at this point when the placenta was supposed to have taken over the hormonal production? Can you guive me a light here please? Thanks a lot!

Dr. Braverman

2027 Posts
RE: Low oestradiol during pregnancy Posted on: Jul 5, 2014 at 11:17am
I would not worry about the estrogen level at this point, I would follow the advice of your doctors. There is no data on low estrogen at this stage of pregnancy and poor outcome.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Mayaus

10 Posts
Reply RE: Low oestradiol during pregnancy Posted on: Jul 7, 2014 at 10:22pm
Thanks so much Dr Braverman!

Dr. Braverman

2027 Posts
RE: Low oestradiol during pregnancy Posted on: Jul 8, 2014 at 4:38am
you are welcome.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Mayaus

10 Posts
Reply RE: Low oestradiol during pregnancy Posted on: Jul 8, 2014 at 5:32am
I was reading online that taking progynova (oestradiol) during pregnancy could harm the developing fetus and now I am freaking out about it because I was on it until the end of 14 weeks. Do you think the baby should be fine? Thanks a lot!

Dr. Braverman

2027 Posts
RE: Low oestradiol during pregnancy Posted on: Jul 8, 2014 at 6:33am
We frequently have our patients on estrogen therapy through 12 weeks and have not seen complications with this. I would advise that you stop reading the internet as there are always "bad" things about everything and the ultmate harm is the worry people go through when they dont have the expereince to interpret correctly what they read.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.