MTHFR and PAI-1 Testing

JBaker110

12 Posts
Reply Posted on: Sep 11, 2012 at 8:44am
Do you feel that the MTHFR and PAI-1 mutation testing should be done as part of all thrombosis testing for recurrent miscarriages? Also, is it necessary to test for a MTHFR mutation with normal (around 8) homocysteine levels?
Jill Baker

Dr. Braverman

2005 Posts
RE: MTHFR and PAI-1 Testing Posted on: Sep 11, 2012 at 9:20am
yes I think both should be part of your workup . There have been studies that have shown early loss due to MTFHR even with normal homocystiene, but I dont personally think this is a very significant issue but at the same time you should always have all of the necessary information in front of you before you decide on any treatment.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

JBaker110

12 Posts
Reply RE: MTHFR and PAI-1 Testing Posted on: Sep 11, 2012 at 9:50am
Wouldn't extra folic acid be what was needed for the MTHFR? Also, if it's not significant why test for it? I do have a mutation for prothrombin, so treatment for the prothrombin mutation would treat for any possible mutation regarding MTHFR and PAI-1, would it not?
Jill Baker

Dr. Braverman

2005 Posts
RE: MTHFR and PAI-1 Testing Posted on: Sep 11, 2012 at 10:41am
yes once you already know you will be on lovenox then I agree no need for addtional testing as it will not change your management. I prefer Metanx for the MTFHR.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

JBaker110

12 Posts
Reply RE: MTHFR and PAI-1 Testing Posted on: Sep 12, 2012 at 8:48am
Is the Metanx in place of a prenatal?
Jill Baker