Metformin and MTHFR


2 Posts
Reply Posted on: Oct 13, 2015 at 6:43pm
I was diagnosed with PCOS but my insulin levels are normal. My doctor did not think I needed metformin but recently (after 1 blighted ovum and 2 chemical pregnancies) wants to put me on it. My only concern is that I tested positive for the MTHFR homogenous C677 mutation. I've been on b vitamins to keep my homocysteine level normal and extra folate (also Lovenox). I read metformin hinders our body's absorption of folate and vitamin b and can raise homocysteine levels. I'm wondering if metformin isn't a good idea for me. Do you have patients taking it with a MTHFR mutation?

Dr. Braverman

2024 Posts
RE: Metformin and MTHFR Posted on: Oct 14, 2015 at 6:37am
Yes I do and I give the Metanx as well.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.