Multiple Failed IVF/FET/Implantation

WCV

1 Posts
Reply Posted on: Feb 25, 2015 at 12:52pm
Dr. Braverman, my husband and I have been through 2 IUI, 4 IVF, 1 FET, 1 Donor Egg IVF, and 1 Donor Egg FET. I respond well to stimulation (15 follicles retrieved on average, 80% mature). Fertilization is between 70%-80% each cycle, no ICSI needed. By day 3 or 5 the number of surviving embryos drops to 1-3.
IVF #1 we transferred two 5 day blasts (graded Fair) = negative.
IVF #2 we transferred one 3 day 8 cell embryo= miscarried at 6w5d b/c of subchorionic hemorrhage (normal karyotype male).
IVF #3 we transferred two 5 day blasts, froze one 6 day blast = negative/chemical (hcg beta 7).
IVF #4 transferred three 7 cell, day 3 embryo = negative.
FET #1 we transferred one 6 day blast=miscarriage (blighted ovum).
At this point we were told egg quality was our issue, we sought a second opinion (day 3 E2 102.0, FSH 11.1, AMH 1.0). We were again told egg quality was the issue so we opted to do an egg donor cycle.
IVF #1 Egg Donor we transferred two 5 day blasts (grade ABB and BBB) = negative.
Donor Egg FET #1 we transferred two 6 day blasts (grade A hatching and AB) = negative.
I have regular cycles and ovulate regularly. No history of endometriosis, no PCOS, HSG was normal/clear, 3 Sonohysterography normal, Hystoscopy found small amount of webbing, otherwise healthy and normal uterus. We are left wondering if egg quality should be our main concern; or if implantation possibly caused by immune issues is our real problem… or both. In your opinion where should our focus be?

Dr. Braverman

2027 Posts
RE: Multiple Failed IVF/FET/Implantation Posted on: Feb 26, 2015 at 6:10am
As you have failed donor egg cycles the focus has to be on implantation first and ruling out immune issues. Many of these immuen issues however can also affect egg quality so finding the diagnosis might treat both problems and many patients are able to get pregnant with their own embryos.
Fill out a consult form on the website and we will schedule a free 10 min consult so I can discuss your case with you.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.