Should I redo testing?


2 Posts
Reply Posted on: Jun 9, 2012 at 6:01pm
I am 38 yo and preparing to undergo IVF in September for my second child. Our infertility diagnosis is male factor due to a vasectomy with 2 failed attempts at reversal. We are using cryopreserved sperm for IVF wiith ICSI. I have a history of Graves disease which was placed into remission with methimazole (never had RAI) several years ago. During my first IVF cycle in Jan 2010 it was discovered that I was now hypothyroid and I was placed on Synthroid (burned out Graves vs concomitant Hashimoto's) My anti-TPO antibodies were over 700 at this point.

My first cycle resulted in a chemical pregnancy very early. I am a poor responder with an FSH of around 11. My AMH currently is 0.57. Although I only experienced a single loss, I began to seek answers about might have caused it so I could do whatever I could before my next cycle. My RPL panel revealed that I was hetero for Factor V Leiden and had a mild Protein S deficiency (57). Further workup revealed elevate Nka at around12.5% and intralipids were recommended. All other testing was WNL. During my second and successful cycle I did immune treatment including steroids, lovenox, and intralipids. I did not have support for the intralipids from my RE but he was aware of them and OK with me doing them through the RI that I had consulted with. I also did extensive supplementation and acupuncture during this cycle.

My daughter is now 13 months old and we are preparing to do a cycle in September to hopefully conceive a sibling. I have started taking a list of supplements that I will list below.

Myo-Inositol 2000 mg BID
melatonin 3 mg QHS (Is this OK with auto immune thyroid disease?)
L-Arginine 1000 mg BID
CoQ10 200 mg BID
Fish Oil TID
DHEA 25 mg TID
selenium 200 mcg
zinc 50 mg
Just ordered Maxi-Flavone and will start once it arrives
Vitamin C BID
Vitamin E 400 IU QD
Vitamin D 5000 IU QD
Magnesium Citrate 400 mg QHS (this I actually take to help with my IBS)

I have heard some conflicting results on the use of some of these supplements, particularly with auto-immune disease, and I definitely don't want to make things worse. I plan on doing the Lovenox, steroids, and intralipids for this cycle as well

My ultimate questions are these.
1. Is there anything in my supplement list that could be harmful
2. Are there any additional supplements I should be taking?
3. Since all my testing was done 2 years ago, should it all be redone or is it OK to proceed with the same protocol as I used with my successful cycle? I hate to spend a whole lot of extra money if it isn't necessary but considering we are only able to conceive via IVF I want to make sure that I have done everything I can to ensure success.

I thank you for your time and I look forward to hearing from you.


Dr. Braverman

2024 Posts
RE: Should I redo testing? Posted on: Jun 10, 2012 at 6:53am
I would try and duplicate what has worked for you before. I think the supplements you are on are fine in autoimmune syndromes. Of course I have not had a chance to look at any of your immune testing, but duplicating success is always a good starting point and based on your history alone I see no reason why it should not work again.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.


2 Posts
Reply RE: Should I redo testing? Posted on: Jun 10, 2012 at 11:12am
Thank you very much for taking the time to answer my question. I greatly appreciate it.



1 Posts
RE: Should I redo testing? Posted on: Aug 15, 2012 at 9:47pm
Buckeyettc, from your name, can i ask if you are in Central Ohio and if so, who is the RI you have seen to do the intralipid treatment as the RE I am seeing will not prescribe it either? if you wouldn't mind and you are in Central Ohio, would you mind responding via e-mail? I can be reached at

thanks so much!!!