Some Advice please Dr B

Hedger

16 Posts
Reply Some Advice please Dr B Posted on: Oct 25, 2011 at 8:24pm
Hi i am 37 years old and never been pregnant as far as i know. Ttc for 5 years
4 failed IUI's although quite a goodfollicle response
2 failed IVF's - (2010 and 2011) poor response to Gonal-F (1 follicle but no eggs and then second time with 450iu for 6 days, no follicles).
FSH was 14.1 at last IVF, took DHEA FSH went to 12.5, now 8.3
AMH is 5.9

Recently Diagnosed with Hashimoto's, positive antithyroid antibodies.
Immune testing
Problem results =
very high Thyroid Antibodies >3000,
mildly positive ANA speckled pattern,
CD3% 85.3% (60-85)
CD56% 11.6 (2-12)
CD19+, CD5+ cells 22.2% (2-12)
Awaiting LAD, hidden C, DQa results
Hysteroscopy and laparoscopy - left ovary slightly adhesed to blood vessel, seperated last week

I have recently been prescribed 50mg thyroxine.
What would your assessment be?
Hashimoto's
rheumatoid arthritis
positive antithyroid antibodies.
Immune testing notable results =
very high Thyroid Antibodies >3000

mildly positive ANA speckled pattern

upper range CD3% 85.3% (60-85) and CD56% 11.6 (2-12) 
and very high CD19+
CD5+ cells 22.2% (2-12)

Dr. Braverman

1998 Posts
Re: Some Advice please Dr B Posted on: Oct 26, 2011 at 1:53am
There may be an autoimmune oophoritis (attack against the ovaries) as the cause of your poor response and elevated FSH. You should at least have anti ovarian antibodies drawn. There are other options in your IVF such as HGH that you could try to improve follicle count.

There are many other possibilities , I would be happy to guide you in your workup if you need.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Hedger

16 Posts
Reply Re: Some Advice please Dr B Posted on: Oct 26, 2011 at 8:37am
Thank you Dr B for your reply. Can I ask what is HGH?
What protocol would you recommend for someone like me? Short/Long/Microflare/Flare?
Hashimoto's
rheumatoid arthritis
positive antithyroid antibodies.
Immune testing notable results =
very high Thyroid Antibodies >3000

mildly positive ANA speckled pattern

upper range CD3% 85.3% (60-85) and CD56% 11.6 (2-12) 
and very high CD19+
CD5+ cells 22.2% (2-12)

Dr. Braverman

1998 Posts
Re: Some Advice please Dr B Posted on: Oct 26, 2011 at 10:00pm
HGH is human growth hormone 4IU per day, and the best results seem to be from the flare protocol(as far as highest yield of genetically normal embryos).
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.