Sperm Fragmentation

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Sperm Fragmentation Posted on: Sep 29, 2010 at 11:00am
Hi Dr. Braverman,

My husband has severe male factor. Does sperm fragmentation have a role in pregnancy loss?

Thanks

Ann

Dr. Braverman

2005 Posts
Re: Sperm Fragmentation Posted on: Sep 29, 2010 at 3:39pm
Yes absolutely, in fact when there is a sperm morphology issue we always order a DNA fragmentation test as well as an oxidative stress assay on the sperm, both can affect the quality of the DNA that is injected into the egg and play a significant role in the success of the embryo implanting properly and continuing on to a normal pregnancy.
There are treatments for very high DNA fragmentation as well as high Oxidative stress assays. Its important to note that the feeling was the IVF with ICSI(intra cytoplasmic sperm injection) corrected all cases with abnormal sperm morphology, but recent literature has shown that in this population of men even the normal shaped sperm selected by ICSI still have a moderate amount of DNA fragmentation. It is however still the best treatment along with medical therapy for the man.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.