natural killer cell uterine biopsy vs blood levels

simone

21 Posts
Reply Posted on: Aug 20, 2015 at 2:24am
Hi there,

Just wondered if you do uterine biopsies for assessing natural killer cells? I would think that the blood picture and percentages could be drastically different to what is happening in the uterus where it all happens? I just wonder how blood numbers can be used to determine treatment and dosages etc when the numbers in the uterus are unkown? Also, do you feel that weekly intralipids can supress the natural killer cells well - we don't have cover for IVIG here in Australia no matter what insurance... My numbers in blood CD56 was 19.5% (RFU testing) and 50:1 was 29%.

Dr. Braverman

2017 Posts
RE: natural killer cell uterine biopsy vs blood levels Posted on: Aug 20, 2015 at 12:06pm
You are starting with a wrong conclusion , that just knowing what NK cells are will help in a diagnosis. NK cells are a very small part of a workup and while the uterine lining is the best place to look for as an ednpoint for immune rejectoin , the evidence for the etiology is in the blood. But requires a much broader investigation. A rec for Intralipids vs IVIG can not and should not be based solely on NK cell testing.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

simone

21 Posts
Reply RE: natural killer cell uterine biopsy vs blood levels Posted on: Aug 20, 2015 at 11:22pm
I understand that you can't use natural killer cells alone in the diagnosis and treatment, but my question was more in relation to how can you tell how bad the natural killer cell numbers are in the uterus by using the blood counts? Aren't these pictures sometimes completely different or are they inter-related - ie high in blood, then high in uterus?

Dr. Braverman

2017 Posts
RE: natural killer cell uterine biopsy vs blood levels Posted on: Aug 21, 2015 at 8:54am
they are 2 different cells. Uterine NK cells are necessary for implantation and their activation is critical for blood vessel development. They have different characteristics then blood (peripheral NK cells) they are not the same and have completely different modes of action. the ability to quantify an NK cell in the uterus without testing its cytokine production and activity is a complete waste of time.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.