why do so many have miscarriages around the heartbeat time

Happyrn

33 Posts
Reply Posted on: Mar 15, 2015 at 11:23pm
Hi,
I have read over and over and over again on the reproductive immunology board and other boards that women are having miscarriages around the same time as the heart starts beating. What is the connection with this event and what can be done to prevent miscarriage from happening at this time?
I also have that same problem in that I ALWAYS miscarry before 7 weeks- primarily around 5.5-6. something weeks. (PS I am currently conducting a survery to see if we have any similar conditions). I am also coming to see you this week. Thanks in advance!

Dr. Braverman

2027 Posts
RE: why do so many have miscarriages around the heartbeat time Posted on: Mar 16, 2015 at 7:46am
There are different immune causes for pregancy loss. Those that continuously occur at around 6-7 weeks are ususaly due to an "adaptive" immune response. i.e. a response from the maternal immune system against the paternal genetics on the embryo . This genetic component starts to be released into the maternal blood stream in little packages called "exosomes" and these contain the complete genetic material of the father which up until that point is mostly hidden from the maternal immune system. The embryo only has minimal paternal genetics so it is not until this exosome phase the maternal immune system becomes aware of all of the genetics.
I hope that helps.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Happyrn

33 Posts
Reply RE: why do so many have miscarriages around the heartbeat time Posted on: Mar 16, 2015 at 11:33am
Thank you for your prompt reply. IF this is the case, what can be done about this? LIT? high doses of pred? (I was on 30 mg daily and that did not work). Many people are waiting on your response to this.
THank you in advance!

Dr. Braverman

2027 Posts
RE: why do so many have miscarriages around the heartbeat time Posted on: Mar 16, 2015 at 11:37am
It all starts with the correct workup and diagnosis. That is what dictates the treatment. LIT in my opinion is of no value in most of these cases. There are so many therapies that can help this but first we have to decide if this is antibody mediated or cellular mediated. If cellular is it mostly and adpative immune response or this there contribution from innate immunity (i.e. T cells vs NK cells).
It is not a simple answer (if it was I would be out playing golf all day, but of course Im a terrible athlete so probably wouldnt anyway!).
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.

Happyrn

33 Posts
Reply RE: why do so many have miscarriages around the heartbeat time Posted on: Mar 17, 2015 at 5:21pm
Another question from gals on the repro immune board who have this same issue, this is what they wrote:

With respect to getting his couples immune panel done, I wonder if it would be most useful for someone with this issue to get it done before pregnancy or during a pregnancy (with the understanding that it would likely be too late to save that pregnancy--but just to see what the nka/cytokines/etc are doing during it, especially if everything would be normal outside a pregnancy.)

We think you would do well at golf by the way! :0)

Dr. Braverman

2027 Posts
RE: why do so many have miscarriages around the heartbeat time Posted on: Mar 19, 2015 at 7:38am
Information during pregnancy is better as it gives me a good idea of the immune response to the pregnancy. But having it prior to preganncy is still useful as I can still make a diagnosis of the predisposing cuases and the underlying immune issues that most have.
Dr. Jeffrey Braverman MD FACOG
Medical Director
Braverman Reproductive Immunology P.C.