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Endometriosis Causing Infertility
Failed IVF Cycles, Miscarriages and Endometriosis
The condition known as endometriosis occurs when the tissue that normally lines the inside of the uterine cavity (endometrium) grows in other areas of the body - usually in the abdominal cavity. This condition can cause pain, irregular bleeding, pain during relations or during bowel movements. There are, however, many cases of endometriosis where there are no symptoms at all and these cases are not discovered until a patient has had an operative procedure called a laparoscopy. At our practice we investigate into endometriosis if younger patients have had unexplained infertility,
failed IVF, failed
donor egg cycles or
Endometriosis can cause infertility and recurrent miscarriages. Many centers assume that the only reason for recurrent miscarriage in patients with endometriosis is egg quality issues, when in fact many are due to immunologic rejection of a pregnancy. In fact many patients who come to our practice who were told they required donor egg due to their endometriosis were in fact found to have immune causes that we successfully treated and were able to help them conceive using their own eggs! The autoimmune nature of endometriosis can affect egg quality by elevating the intra-abdominal levels of inflammatory cytokines that the ovaries are directly exposed to. This causes a condition known as oxidative stress and raises the level of a "toxic" chemical called ROS (reactive oxygen species) that the eggs are exposed to. (This can be treated to improve egg quality). In fact in IUI cycles or in patients trying to conceive on their own, these same ROS molecules can essentially deactivate the sperm sometimes requiring IVF even when there are no signs of tubal blockage.
Patients with endometriosis have a high level of an anti-inflammatory cytokine (a cytokine that turns away attacking immune cells) called IL 10. This protects the endometriosis lesions in the abdomen from the patient's immune system thus allowing it to grow unimpeded. The body's response is to activate the immune system even more in an attempt to eradicate the endometriosis. It is this activation that can make it difficult for an implanting embryo to turn off the immune system at the site of implantation (something it must do to survive). At our practice we can test for signs of this immune response and successfully treat this problem.
Patients with endometriosis will clearly benefit from surgical debulking in order to reduce the effects of endometriosis on egg quality as well as the immunological effects on implantation, which if not addressed, can lead to failure to conceive or recurrent miscarriages. Renowned Endometriosis Surgeon, Dr Tamer Seckin is among a very limited number of specialized surgeons in the United States who possess advanced techniques for the Deep Laparoscopic Excision of Endometriosis. This is the best method to assure a patient of the maximum benefit of surgery and I highly recommend him for these types of procedures.
Treating Pregnancy Loss Caused by Endometriosis
If you have experienced problems with infertility or recurrent miscarriage, Dr. Braverman is available to provide you with help. Should your pregnancy loss be caused by endometriosis, there is treatment available that may correct the problem and allow you to successfully become pregnant. Dr. Braverman is a medical professional with decades of experience, and his practice is devoted to helping women who are unable to maintain pregnancy due to immunological problems. We have been voted the best infertility practice on Long Island for three years in a row, and we are the only practice that has been authorized to officially use the name "reproductive immunology" in New York State. We possess treatment methods for a wide variety of immune related infertility issues, and we are available to provide you with help in your specific case. If your
miscarriages have been brought about by endometriosis, we will devise a personalized medical plan that is intended to effectively address the condition and bring about its resolution.
If you have suffered from a pregnancy loss that was caused by endometriosis, we could have the answers you need. Contact Braverman IVF & Reproductive Immunology today to learn about the treatments available to you.