Autoimmue & Allioimmune- what to do?

Jean

Reply Posted on: Jul 5, 2013 at 6:17am

Dear Dr. Braverman,

After 2 failed IVF Cycles that were textbook perfect and I am 33, I found out that I am autoimmune and allioimmune. Before I start another cycle with our 5 frozen embryos remaining, I wanted to get your thoughts on the recent panel we recieved.

DQ Alpha (hubby) 0101(1.1)/0303(NA) - (me) 0101(1.1)/0102 (1.2)

DQ Beta (hubby) 03, 05 (me) 05, 06

HLA- A (hubby) 02, 02 (me) 01, 11

HLA-B (hubby) 44, 44 (me) 07, 35

HLA-C (hubby) 04, 05 (me) 04, 07

HLADRB1 (hubby) 01, 04 DRB4 Present- (me) 01, 15 DRB5 Present

Based on what I have researched, we are a 50% Match so our embryo has 50% chance of being a Match and will not make it. You reference there are other implications with being a HLA-C Match, can you explain? Do we have an issue?

I am looking to do a frozen embryo cycle with 2 of our embryos with IVIG and Pregnason, etc., but what are our chances of success?

We found all this out after we froze our embryos so I do not know if they are chromosomally normal or if they are a "match."

Do you recommend transferring 1 or 2 embryos at time in this situation?

Thank you very much!

Dr. Braverman

2026 Posts

RE: Autoimmue & Allioimmune- what to do? Posted on: Jul 5, 2013 at 6:50am

see my reply to your second post. I do not beleive that transferring one or two has an impact on the immune issues.

Braverman Medical Team
Braverman Reproductive Immunology P.C.

Jean

10 Posts

Reply RE: Autoimmue & Allioimmune- what to do? Posted on: Jul 5, 2013 at 7:11am

Thank you Dr. Braverman, I feel better now chosing to transfer 2.

One last question on this issue- Is there any testing in the future that can be done on the embryos to see if it is a match?

Dr. Braverman

2026 Posts

RE: Autoimmue & Allioimmune- what to do? Posted on: Jul 5, 2013 at 7:21am

NK cells do not attack an embryo because of a DQalpha match. DQlapha is not even on the surface of the embryo only HLA C is . The sensitizaton for paternal tolerance takes place at the sperm and also later in the pregnancy once the developed pregnancy begins shedding the DQalpha.
Please read the HLA blog to get a better understanding of these issues. I tried to keep it simple.

Braverman Medical Team
Braverman Reproductive Immunology P.C.

Jean

10 Posts

Reply RE: Autoimmue & Allioimmune- what to do? Posted on: Jul 5, 2013 at 7:40am

Since we are a partial match for the HLA-C will there be issues for us in transferring the embryos?

Dr. Braverman

2026 Posts

RE: Autoimmue & Allioimmune- what to do? Posted on: Jul 5, 2013 at 8:19am

no only see this with complete matches at HLA C.

Braverman Medical Team
Braverman Reproductive Immunology P.C.

hopefulMe

4 Posts

RE: Autoimmue & Allioimmune- what to do? Posted on: Jul 17, 2013 at 9:39am

Sorry I know these questions are for Dr. Braverman but I could not help but notice your husband has similar HLA to my husband and you also have the DR2-DQ6 (DRB15 and DQB 06) haplotype that I do.

Your husband is also contributing a C2 allele - do you know your KIR?

Please post back if IVIG worked with your FET.

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