Egg Mitochondrial Restoration Program - Treatment for those with egg quality issues caused by Endometriosis and PCOS (Correctable Recurrent Aneuploid Conversion Syndrome)

Posted By Braverman IVF & Reproductive Immunology || 21-Apr-2016

At Braverman IVF & Reproductive Immunology we have initiated a COMPLETE program to minimize damage to oocyte (egg) mitochondria and to maximize oocyte mitochondrial function. It is important to understand that many areas of treatment are available and ALL should be employed to make every effort to improve mitochondrial function and thus improve embryo quality and behavior.

During our years of providing IVF treatment to patients from all over the world, we have found that many of the failures in patients suffering from Endometriosis and Polycystic Ovary Syndrome (PCOS) are caused when mitochondria, which are responsible for creating the energy embryos need to correctly divide the nucleus symmetrically and keep the embryo in the “euploid” (normal genetic) state and support life, fail to function as they should. When they do, abnormal division of the nucleus ensues and the embryo converts to an aneuploid (abnormal genetic) state leading to failed implantation or miscarriage (or chemical pregnancy).


For our patients in whom we diagnose Endometriosis, below is our treatment plan to optimize embryo quality and behavior, even in those where FSH is already elevated or AMH is low. Many patients are incorrectly told when these levels become abnormal that they are entering menopause, when in fact, they have a correctible issue that will not return them to a normal egg count but most importantly (and mostly misunderstood by many IVF centers) it will repair the environment the eggs that are left develop in, and these eggs can return to being developed normally leading to improved embryo behavior. This is why many patients who come to our center who are told they need egg donation are able to have biologic children with our program. While we cannot promise success for all, the treatments do work and should be attempted prior to seeking egg donation. (See our case reports)


  • Surgery: Patients with endometriosis undergo complete excision surgery by Dr. Vidali, our world renowned endometriosis surgeon. These surgeries are done robotically for patients all around the world that travel to our center. He specializes in endometriosis surgery for those with infertility and understands the care that must be taken to optimize results while taking caution to protect ovarian function.
  • G-CSF treatment: Our own research here at BRI shows that granulocyte-colony stimulating factor (G-CSF) treatment increases follicular fluid levels that are associated with improved egg quality, with improved mitochondrial function a most likely reason. For this reason we now offer GCSF therapy during your IVF stimulation to continue the process of improving egg development in these cases.
  • Supplements: Reproductive Immunology Supplements has created a line of supplements that may help improve mitochondrial function by lowering levels of inflammatory cytokines that have been associated with mitochondrial damage in patients with endometriosis. The first product is Endo Optimize and soon a probiotic with similar activities will be released as well. Research has proven that the ingredients in these supplements have a positive impact on mitochondrial function and can even inhibit the growth of endometriosis lesions.
  • EmbryoGen culture medium: We use this specialized culture medium once your eggs are retrieved. It has been proven to improve embryo quality and behavior and lower failed implantation and miscarriage rates.


Many patients come to our center with history of many eggs and embryos but poor quality or simply failed implantation, even with PGS tested normal embryos. Many are found to have high AMH, an excessive number of eggs during their stimulation, or signs of insulin resistance (such as Gestational Diabetes). Many come here not aware they have PCOS or insulin resistance as the cause of their mitochondrial dysfunction simply because they don’t present with the “typical’ symptoms of PCOS, which are not necessary to make the diagnosis and initiate correct treatment.


  • Surgery using ovarian drilling in our resistant cases has shown significant improvement in egg and embryo quality.
  • Metformin treatment prior to the start of an IVF stimulation or at least 4 weeks prior to trying IUI or natural relations.
  • Probiotics (Reproductive Immunology Supplements will soon release a new line of probiotics to help improve egg and embryo quality in both endometriosis and PCOS patients).
  • Inositol for those that do not use Metformin has also shown marked benefit in improving egg and embryo quality (soon to be released by Reproductive Immunology Supplements)
  • EmbryoGen culture medium (see above)
  • IVF stimulation that minimizes the impact of high estrogen levels in PCOS patients – levels that have been shown to affect mitochondrial function.

No other clinic uses the comprehensive, innovative approach we do here at Braverman IVF & Reproductive Immunology. We have a thorough, research-based understanding of mitochondrial dysfunction and its effect on fertility, as well as the various ways to treat this condition. No matter where you live in the world, we encourage you to get in touch with our doctors and to seek treatment at our New York facility. Please visit our website to learn more about insurance & financing options as well as information on how to prepare for your treatment.

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