Lack of inflammation may lead to IMPLANTATION failure

Dr. Braverman

2026 Posts
Reply Lack of inflammation may lead to IMPLANTATION failure Posted on: Nov 4, 2011 at 3:07am
A new study out of China, confirms what has been our belief , that at the time of implantaion , the inability to produce a local inflammatory response may be responsble for many IVF failures. This is not true for recurrent miscarriages, but just those that get a negative beta HCG all together. They looked at the level of TH17(an inflammatory) ctyokine and compared it to the level of T regulatore cytokines(such as IL10) and when the ratios were low(i.e. TH17 was low) there was a significant decrease in positive beta HCGs.

This leads us to two conclusions

we should be careful to not arbitrarily suppress with steroids/intralipids/or IVIG unless we know there is an increased state of production of inflammatory cytokines as this could actually decrease the chances of pregnancy. We have seen many cases come to our clinic with such a problem as outside clinics over treated and they responded to removal of the suppressnants and addition of correct therapies that led to a successful pregnancy

there may be some patients that have an inherent defect in the production or lack there of of IL10 or TH1/Inf gamma or even TNF that can lead to implantation failure. we have begun to test for these genetic problems in our immune panels.
Braverman Medical Team
Braverman Reproductive Immunology P.C.

carnelian

14 Posts
Re: Lack of inflammation may lead to IMPLANTATION failure Posted on: Nov 28, 2011 at 7:25pm
please could you give the authors/title of the article?

thanks!