New Sloane Kettering Study & TReg Involvement

Posted By Braverman IVF & Reproductive Immunology || 13-Sep-2012

A new study out of Sloan Kettering Hospital in NYC has shown that Regulatory T cells (Tregs) that are produced by mammals (humans), outside of the thymus, may have as their primary purpose assisting the implantation of the mammalian placenta. Defects in the production of these "peripheral" or "extra thymic" Tregs may be involved in the cause of recurrent pregnancy loss. This conversion of Tregs from their "naïve" or "resting" state appears to be controlled by TGF beta and low levels or polymorphisms (abnormal shapes) of TGF beta may also be one of the contributing failures in miscarriages. At Braverman IVF & Reproductive Immunology we will begin looking for these issues with our patients as we attempt to establish a laboratory technique for this.

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