Regulatory T Cells Protecting the Embryo

How Failure of Regulatory T Cell Functioning Causes Miscarriage

One of the ways in which immune tolerance is generated for an embryo is by the production of a special white blood cell called a regulatory T cell - also known as a T Regulator Cell (Treg). These begin to increase in number during the second half of the menstrual cycle in preparation for an expected pregnancy. Sperm entering the body also plays a part in the further development of these cells. The regulatory T cells go to the uterine lining and start to deactivate cells that would normally attack an invading embryo. They deactivate cells that would attack directly as well as those that would produce chemicals which cause inflammation and thus invite other immune cells to attack the area. Another issue they address it that of cells which "report" a foreign presence and thus cause the production of more cells to attack that tissue.

In these ways, regulatory T cells prevent the immune system from causing a rejection of the embryo. These cells also support these efforts by releasing chemicals that induce the formation of more regulatory T cells to assist with these protective measures. They also release an anti-inflammatory chemical to prevent inflammation from prompting an attack by the immune system. This same chemical also leads to the production of protective antibodies by the mother's B cells that further shield the embryo from the mother's immune system. As the body is designed to support pregnancies, it is when these mechanisms are not functioning correctly that multiple miscarriages can result.

You Options to Prevent Miscarriage: Comprehensive Treatment

If you have been suffering recurrent miscarriages, Dr. Braverman can conduct a thorough examination and devise a treatment program tailored specifically to you. Our entire team has been part of the practice for at least 20 years and is dedicated to supporting you through this trying time. So don't wait! Contact Braverman IVF & Reproductive Immunology to see how we can help you successfully complete pregnancy.

If you have experienced pregnancy losses, contact Dr. Braverman for skilled treatment.