CD28 NEW T CELL MARKER TO DIAGNOSE IMMUNE INJECTION

A recently published study has shown that patients that fail to produce T cells with a CD28 marker lose their ability to "delete" or 'destroy" T cells that are normally programmed to attack the paternal (fathers) genes on the invading embryo. That is any time an embryo implants the mothers immune system ALWAYS makes T cells that are programmed to attack the embryo, but a special line of T cells with a CD28 marker on them are necessary to "delete" or "destroy" this attacking group of T cells. When the CD28 T cells are low in number or absent in animal studies this has almost ALWAYS led to immune rejection of the pregnancy.

We have recently added this test to our immune profile and it is now one more of the many cells we look at here at Braverman IVF & Reproductive Immunology to help us decide if the immune system is playing a part in the pregnancy losses so many of our patients present to us with.