Posted By Dr. Braverman || 8-Nov-2012

Research has now shown that PCOS not only activates the endocrine system (i.e. high blood sugars, high LH, high male hormone levels, and high fasting insulin), but also the immune and coagulation systems. Activation of a key pathway called the NF-KB, triggered by high glucose levels (and the by-products of glucose), leads to marked inflammation, release of inflammatory cytokines such as TNF (tumor necrosis factor), and also increased insulin resistance. In turn the destruction of fat containing cells in these patients (adipose cells) also triggers the coagulation system. All of these pathways are intertwined and activation of the NF-KB system occurs even in PCOS patients that are not overweight.

Understanding the relationship between these systems and our approach to treating PCOS is why our treatment at Braverman IVF & Reproductive Immunology is so successful. It is because we treat all of the triggers that can activate the NF-KB Pathway.

There are supplements that have been shown to actually decrease the NF-KB pathway activation and also decrease the by-products of glucose breakdown that lead to turning off of these pathways. In addition, Metformin also repairs the activation of these pathways. If these pathways are activated and untreated it can lead to early miscarriages, which is one of the most common presentations to our infertility center.

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